Office 365 (Outlook Client for Mac) - Send Automatic Replies When You are Out of the Office

In Outlook, you can create custom automatic replies when you will be out of the office. 

For the most current information on how to create automatic replies, please refer to this Microsoft help article and view the "Exchange" option:  https://support.office.com/en-us/article/send-automatic-out-of-office-replies-from-outlook-for-mac-4e07ab75-beda-4f9e-bcdc-44471ebacdee